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truA [2017-8-11 16:0:3]
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truA [2017-8-11 16:0:3]

pseudouridylate synthase I, universally conserved protein
locus
BSU01480
pI
6.65
mw
27.90 kDa
protein length
247 aa Sequence Blast
gene length
741 bp Sequence Blast
function
tRNA modification
product
pseudouridylate synthase I
essential
no
ec
5.4.99.12
synonyms
ybaH
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

    • Gene

    Coordinates
    152,937 → 153,680

    The protein

    Catalyzed reaction/ biological activity

  • tRNA uridine = tRNA pseudouridine (according to Swiss-Prot)

    • Protein family

  • tRNA pseudouridine synthase truA family (according to Swiss-Prot)

    • Structure

  • [PDB|1VS3] (from ''Thermus thermophilus'', 42% identity) [Pubmed|17114947]

    • Additional information

  • [SW|universally conserved protein]

    • Expression and Regulation

    Operons

    genes
    [gene|84334531D66BE7524021C4B40C3FA05AAFE0D7A6|truA]-[gene|B495FFC63413D518138F8C2F3FBC894038C97E0E|rplM]-[gene|C8E45EDBCD0CFF353D1D66E6D77FD81E976BC0BC|rpsI]
    description
    [pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, [Pubmed|11948165], in [regulon|stringent response|stringent response]

    • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
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    References

  • 11948165,17114947